PAMP-12 Inhibitor

Potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2nM). Corresponds to amino acids 9 to 20 of proadrenomedullin.

Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem. Biophys.Res.Commun. 330 1146 PMID:
Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem. Biophys.Res.Commun. 330 1146 PMID:
Lansu et al (2017) In silico design of novel probes for the atypical opioid receptor MRGPRXNat.Chem. Biol. 13 529 PMID:
Lansu et al (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat.Chem. Biol. 13 529 PMID:

Small volumes of PAMP-12, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5763878 is an inhibitor targeting PAMP-12. Also known as PAMP-12 (human, porcine).