gamma1-MSH Inhibitor

Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity in vivo.

Versteeg et al (1998) Melanocortins and cardiovascular regulation. Eur.J.Pharmacol. 360 1 PMID:
Versteeg et al (1998) Melanocortins and cardiovascular regulation. Eur.J.Pharmacol. 360 1 PMID:
Lindblom et al (1998) Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain. Brain Res. 810 161 PMID:
Lindblom et al (1998) Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain. Brain Res. 810 161 PMID:
Jansone et al (2004) Opposite effects of gamma1- and gamma2-melanocyte stimulating hormone on regulation of the DArgic mesolimbic system in rats. Neurosci.Lett. 361 68 PMID:
Jansone et al (2004) Opposite effects of gamma1- and gamma2-melanocyte stimulating hormone on regulation of the DArgic mesolimbic system in rats. Neurosci.Lett. 361 68 PMID:

Small volumes of gamma1-MSH, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5763890 is an inhibitor targeting gamma1-MSH.