[D-TRP8]-gamma-MSH Inhibitor

Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.

Grieco et al (2000) D-amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp8 on human MC3 receptor selectivity. J.Med.Chem. 43 4998 PMID:
Grieco et al (2000) D-amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp8 on human MC3 receptor selectivity. J.Med.Chem. 43 4998 PMID:
Getting et al (2006) [D-Trp8]-gamma-Melanocyte-stimulating-hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol.Pharmacol. 70 1850 PMID:
Getting et al (2006) [D-Trp8]-gamma-Melanocyte-stimulating-hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol.Pharmacol. 70 1850 PMID:
Patel et al (2010) Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J. 24 4835 PMID:
Patel et al (2010) Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J. 24 4835 PMID:

Small volumes of [D-Trp8]-gamma-MSH, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5763891 is an inhibitor targeting [D-Trp8]-gamma-MSH.