CALP2 Inhibitor

Cell-permeable calmodulin (CaM) antagonist that binds to the EF-hand/Ca2+-binding site. CALP2 has been demonstrated to inhibit CaM-dependant phosphodiesterase activity and increase intracellular Ca2+ concentrations by modulating Ca2+-channel activity. CALP2 has also been shown to be a potent activator of alveolar macrophages.

Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861 PMID:
Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861 PMID:
Ten Broeke et al (2001) Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 15 1831 PMID:
Ten Broeke et al (2001) Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 15 1831 PMID:
Ten Broeke et al (2004) Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab. Invest. 84 29 PMID:
Ten Broeke et al (2004) Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab. Invest. 84 29 PMID:

Small volumes of CALP2, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5763907 is an inhibitor targeting CALP2.