[D-Phe12,Leu14]-Bombesin Inhibitor

Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2uM. Inhibits amylase release in vitro (IC50 = 4uM) and attenuates bombesin-mediated suppression of food intake in vivo.

Heinz-Erian et al (1987) [d-Phe12]bombesin analogues: a new class of bombesin receptor antagonists. Am.J.Physiol. 252 G439 PMID:
Heinz-Erian et al (1987) [d-Phe12]bombesin analogues: a new class of bombesin receptor antagonists. Am.J.Physiol. 252 G439 PMID:
Merali et al (1988) (d-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists. Synapse 2 282 PMID:
Merali et al (1988) (d-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists. Synapse 2 282 PMID:
Flynn (1997) Bombesin receptor antagonists block the effects of exogenous bombesin but not of nutrients on food intake. Physiol. Behav. 62 791 PMID:
Flynn (1997) Bombesin receptor antagonists block the effects of exogenous bombesin but not of nutrients on food intake. Physiol. Behav. 62 791 PMID:

Small volumes of [D-Phe12,Leu14]-Bombesin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5763914 is an inhibitor targeting [D-Phe12,Leu14]-Bombesin.