Lys-[Des-Arg9]Bradykinin Inhibitor

Endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripheral vascular resistance in vivo. 16-fold more potent than [Des-Arg9]-Bradykinin (Cat No. 3005).

Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp. Ther. 259 997 PMID:
Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp. Ther. 259 997 PMID:
Regoli et al (2001) Classification of kinin receptors. Biol.Chem. 382 31 PMID:
Regoli et al (2001) Classification of kinin receptors. Biol.Chem. 382 31 PMID:
Leeb-Lundberg et al (2005) International union of pharmacology. LV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID:
Leeb-Lundberg et al (2005) International union of pharmacology. LV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID:

Small volumes of Lys-[Des-Arg9]Bradykinin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5763916 is an inhibitor targeting Lys-[Des-Arg9]Bradykinin.