PHM27 Inhibitor – PHM 27

Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic beta-islets display enhanced glucose-induced insulin secretion.

Itoh et al (1983) Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature 304 547 PMID:
Itoh et al (1983) Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature 304 547 PMID:
Kato et al (1994) Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. J. Biol.Chem. 269 21223 PMID:
Kato et al (1994) Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. J. Biol.Chem. 269 21223 PMID:
Ma et al (2004) Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem.Pharmacol. 67 1279 PMID:
Ma et al (2004) Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem.Pharmacol. 67 1279 PMID:

Small volumes of PHM27, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5763952 is an inhibitor targeting PHM27. Also known as PHM 27 (human).