RACK1 Inhibitor – Pseudo

Activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC beta linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37 degree C, ensuring rapid and effective uptake of the activator peptide. Once inside the cell, the disulfide bonds are subjected to reduction in the cytoplasm leading to release of the activator peptide.

Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J. Biol.Chem. 269 10444 PMID:
Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J. Biol.Chem. 269 10444 PMID:
Ron and Mochly-Rosen (1995) An autoregulatory region in protein kinase C: the pseudoanchoring site. Proc.Natl. Acad.Sci.U.S. A. 92 492 PMID:
Ron and Mochly-Rosen (1995) An autoregulatory region in protein kinase C: the pseudoanchoring site. Proc.Natl. Acad.Sci.U.S. A. 92 492 PMID:
Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID:
Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID:

Small volumes of RACK1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5763969 is an inhibitor targeting RACK1. Also known as Pseudo RACK1.