[Arg14,Lys15]Nociceptin Inhibitor

Highly potent and selective NOP receptor agonist (EC50 = 1nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, u, delta and kappa receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.

Calo et al (2002) Pharmacological profile of nociceptin/orphanin FQ receptors. Clin.Exp.Pharmacol.Physiol. 29 223 PMID:
Calo et al (2002) Pharmacological profile of nociceptin/orphanin FQ receptors. Clin.Exp.Pharmacol.Physiol. 29 223 PMID:
Okada et al (2000) Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem. Biophys.Res.Commun. 278 493 PMID:
Okada et al (2000) Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem. Biophys.Res.Commun. 278 493 PMID:
Rizzi et al (2002) [Arg14,Lys15]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J.Pharmacol.Exp. Ther. 300 57 PMID:
Rizzi et al (2002) [Arg14,Lys15]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J.Pharmacol.Exp. Ther. 300 57 PMID:

Small volumes of [Arg14,Lys15]Nociceptin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5763984 is an inhibitor targeting [Arg14,Lys15]Nociceptin.