[ALA17]-MCH Inhibitor

Potent melanin-concentrating hormone (MCH) receptor agonist (EC50 values are 17 and 54nM at MCH1 and MCH2 receptors respectively). Displays some selectivity towards MCH1 over MCH2 (Ki values are 0.16 and 34nM respectively).

Bednarek et al (2001) Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. Biochemistry 40 9379 PMID:
Bednarek et al (2001) Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. Biochemistry 40 9379 PMID:
Gao et al (2004) Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and Anal. Biochem. 328 187 PMID:
Gao et al (2004) Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Anal. Biochem. 328 187 PMID:

Small volumes of [Ala17]-MCH, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5763995 is an inhibitor targeting [Ala17]-MCH.