K41498 Inhibitor – K 41498

Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425nM for human CRF2alpha, CRF2beta and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2alpha- and hCRF2beta-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.

Ruhmann et al (2002) Design, synthesis and pharmacological characterization of new highly selective CRF2 antagonists: development of 123I-K31440 as a potential SPECT ligand. Peptides 23 453 PMID:
Ruhmann et al (2002) Design, synthesis and pharmacological characterization of new highly selective CRF2 antagonists: development of 123I-K31440 as a potential SPECT ligand. Peptides 23 453 PMID:
Lawrence et al (2002) The highly selective CRF2 receptor antagonist K41498 binds to presynaptic CRF2 receptors in rat brain. Br.J.Pharmacol. 136 896 PMID:
Lawrence et al (2002) The highly selective CRF2 receptor antagonist K41498 binds to presynaptic CRF2 receptors in rat brain. Br.J.Pharmacol. 136 896 PMID:

Small volumes of K41498, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5764006 is an inhibitor targeting K41498. Also known as K 41498.