GRK2i Inhibitor

GRK2 inhibitory polypeptide that specifically inhibits Gbetagamma activation of GRK2. Corresponds to the Gbetagamma-binding domain and acts as a cellular Gbetagamma antagonist.

Koch et al (1994) Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gbetagamma-mediated signaling. J. Biol.Chem. 269 6193 PMID:
Koch et al (1994) Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gbetagamma-mediated signaling. J. Biol.Chem. 269 6193 PMID:
Macrez et al (1997) A betagamma dimer derived from G13 transduces the angiotensin AT1 receptor signal to stimulation of Ca2+ channels in rat portal vein myocytes. J. Biol.Chem. 272 23180 PMID:
Macrez et al (1997) A betagamma dimer derived from G13 transduces the angiotensin AT1 receptor signal to stimulation of Ca2+ channels in rat portal vein myocytes. J. Biol.Chem. 272 23180 PMID:
Dang et al (2009) Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons. J.Neurosci. 29 3322 PMID:
Dang et al (2009) Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons. J.Neurosci. 29 3322 PMID:

Small volumes of GRK2i, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5764022 is an inhibitor targeting GRK2i.