GRP Inhibitor

Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.

Dudai (2003) Neurobiology: Fear thou not. Nature 421 325 PMID:
Dudai (2003) Neurobiology: Fear thou not. Nature 421 325 PMID:
Schjoldager et al (1991) Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction. Am.J.Physiol. 260 G577 PMID:
Schjoldager et al (1991) Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction. Am.J.Physiol. 260 G577 PMID:
Shumyatsky et al (2002) Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 111 905 PMID:
Shumyatsky et al (2002) Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 111 905 PMID:
Woodruff et al (1996) Bombesin receptors in the brain. Ann.N.Y. Acad.Sci. 780 223 PMID:
Woodruff et al (1996) Bombesin receptors in the brain. Ann.N.Y. Acad.Sci. 780 223 PMID:

Small volumes of GRP, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5764023 is an inhibitor targeting GRP. Also known as GRP (porcine).