DPDPE Inhibitor

DPDPE is selective delta-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2nM), and is antinociceptive in vivo.

Chandrakumar et al (1992) Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions. J.Med.Chem. 35 2928 PMID:
Chandrakumar et al (1992) Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions. J.Med.Chem. 35 2928 PMID:
Clark et al (1986) [D-Pen2,D-Pen5]enkephalin (DPDPE): a delta-selective enkephalin with low affinity for mu1 opiate binding sites. Eur.J.Pharmacol. 128 303 PMID:
Clark et al (1986) [D-Pen2,D-Pen5]enkephalin (DPDPE): a delta-selective enkephalin with low affinity for mu1 opiate binding sites. Eur.J.Pharmacol. 128 303 PMID:
Fraser et al (2000) Supraspinal antinociceptive response to [D-Pen2,5]-enkephalin (DPDPE) is pharmacologically distince from that to other delta-agonists in the rat. J.Pharmacol.Exp. Ther. 295 1135 PMID:
Fraser et al (2000) Supraspinal antinociceptive response to [D-Pen2,5]-enkephalin (DPDPE) is pharmacologically distince from that to other delta-agonists in the rat. J.Pharmacol.Exp. Ther. 295 1135 PMID:

Small volumes of DPDPE, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5764032 is an inhibitor targeting DPDPE.