CRF Inhibitor – Alpha-Helical

Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2alpha and mouse CRF2beta receptors respectively).

Kask et al (1997) Alpha-helical(9-41) revents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226. NeuroReport 8 3645 PMID:
Kask et al (1997) Alpha-helical(9-41) revents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226. NeuroReport 8 3645 PMID:
Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y. Acad.Sci. 885 312 PMID:
Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y. Acad.Sci. 885 312 PMID:
Swerdlow et al (1989) Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by alpha-helical CRF (9-41). Neuropsychopharmacology 2 285 PMID:
Swerdlow et al (1989) Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by alpha-helical CRF (9-41). Neuropsychopharmacology 2 285 PMID:

Small volumes of CRF, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5764043 is an inhibitor targeting CRF. Also known as alpha-helical CRF 9-41.