TC14012 Inhibitor – Tc 14012

MBS5764105 is an inhibitor targeting TC14012. Also known as TC 14012. CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350nM for CXCR7).

Tamamura et al (2003) Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org. Biomol.Chem. 1 3656 PMID:
Tamamura et al (2003) Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org. Biomol.Chem. 1 3656 PMID:
Burger et al (2005) Small peptide inhibitors of the CXCR4 chemokine receptor (CS184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106 1824 PMID:
Burger et al (2005) Small peptide inhibitors of the CXCR4 chemokine receptor (CS184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106 1824 PMID:
Gravel et al (2010) The peptidomimetic CXCR4 antagonist TC14012 recruits beta arrestin to CXCR7: roles of receptor domains. J. Biol.Chem. 285 37939 PMID:
Gravel et al (2010) The peptidomimetic CXCR4 antagonist TC14012 recruits beta arrestin to CXCR7: roles of receptor domains. J. Biol.Chem. 285 37939 PMID:

Small volumes of TC14012, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.