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ShK-DAP22 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764116

Extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >100000… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ShK-Dap22, Inhibitor
Full Product Name
ShK-Dap22
Product Gene Name
ShK-Dap22, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
4012.7
Solubility
Water: 1mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C166H268N54O48S7
CAS Number
220384-25-8

Product References and Citations for ShK-Dap22, inhibitor

Kalman et al (1998) ShK-Dap22, a potent KV1.3-specific immunosuppresive polypeptide. J. Biol.Chem. 273 32697 PMID:
Kalman et al (1998) ShK-Dap22, a potent KV1.3-specific immunosuppresive polypeptide. J. Biol.Chem. 273 32697 PMID:
Robbins et al (2005) Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via KV1.3 channels. J.Physiol. 564 131 PMID:
Robbins et al (2005) Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via KV1.3 channels. J.Physiol. 564 131 PMID:

Other Notes

Small volumes of ShK-Dap22, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ShK-Dap22 purchase

MBS5764116 is an inhibitor targeting ShK-Dap22.
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