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Cytochrome c fragment Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764198

Cytochrome c is a small heme protein found loosely associated with the inner membrane of the mitochondrion. Cytochromes c from certain eukaryotes, including plants and fungi but not higher animals, contains methylated lysine residues at specific positions1.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cytochrome c fragment, Inhibitor
Full Product Name
Cytochrome c fragment (93-108)
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
1805.04
Solubility
DMSO: >=180.5mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C79H133N23O25
SMILES
N[C@](C)([H])C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@](C)([H])C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CC(C)(C)[H])C(=O)N[C@]([H])(C(=O)N[C@](C)([H])C(=O)N[C@@]([H])(C/C1=C/C=C(/O)C=C1)C(=O)N[C@@]([H])(CC(C)(C)[H])C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@](C)([H])C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCCCN)C(=O)O)[C@@](C)(O)[H])[C@](C)([H])CC
In Vitro
Cytochrome c is absolutely required in vitro system for the activation of caspase-3 and caspase-9. When cytochrome c was depleted from HeLa cell S-100 extracts by a monoclonal antibody, the ability to activate caspases was abolished4. t. When cytochrome c was depleted, caspase-9 failed to bind Apaf-1 even in the presence of dATP. The binding was restored when purified cytochrome c was added. These suggest that cytochrome c initiates apoptosis by inducing the formation of the Apaf-1/caspase-9 complex4.

Other Notes

Small volumes of Cytochrome c fragment, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cytochrome c fragment purchase

MBS5764198 is an inhibitor targeting Cytochrome c fragment. Also known as Cytochrome c fragment (93-108).
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