Dynorphin, amide Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

1983.33

DMSO: >=198.3mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

C90H147N31O20

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Dynorphin is produced in many different parts of the brain, including the hypothalamus, the striatum, the hippocampus, and the spinal cord. Dynorphin has been shown to be a modulator of pain response. injecting dynorphin into the subarachnoid space of the rat spinal cord produced dose-dependent analgesia that was measured by tail-flick latency. Analgesia was partially eliminated by opioid antagonist naloxone. dynorphin activates bradykinin receptors, which triggers the release of calcium ions into the cell through voltage-sensitive channels in the cell membrane. Blocking bradykinin receptors in the lumbar region of the spinal cord reversed persistent pain. A multiple pathway system might help explain the conflicting effects of dynorphin in the CNS [3].