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KO-947 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764263

MBS5764263 is an inhibitor targeting KO-947. KO-947 is a potent and specific inhibitor of ERK1/2 kinases. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KO-947, Inhibitor
Full Product Name
KO-947
Product Gene Name
KO-947, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
355.39
Solubility
DMSO: 60mg/mL (168.83mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C21H17N5O
SMILES
O=C1Nc2cc3[nH]nc(-c4ccncc4)c3cc2CN1Cc1ccccc1
CAS Number
1695533-89-1
In Vitro
KO-947 blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling, including mutations in KRAS, NRAS or BRAF, at low nanomolar concentrations.

Product Categories/Family for KO-947, inhibitor

MAPK; ERK

Product References and Citations for KO-947, inhibitor

Burrows F, et al. KO-947, a potent ERK inhibitor with robust preclinical single agent activity in MAPK pathway dysregulated tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5168. doi:10.1158/1538-7445. AM2017-5168.

Other Notes

Small volumes of KO-947, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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