Ethynylcytidine Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

267.24

DMSO: 240mg/mL (898.07mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

C11H13N3O5

C#C[C@@]([C@@H](CO)O[C@H]1N(C=CC(N)=N2)C2=O)([C@H]1O)O

180300-43-0

In both OCUM-2MD3 and LX-1 xenografts, tumor regression is noted and a very potent antitumor effect with a tumor growth inhibition rate on day 15 of approximately 90% or even higher is observed at the minimum toxic doses of Ethynylcytidine on all three administration schedules. In particular, the administration of Ethynylcytidine at 6mg/kg once weekly exhibits a marked tumor-shrinking effect with an IR of 98% against the LX-1 tumor. While Ethynylcytidine treatment,on an either 3 or 5 times weekly schedule has a potent antitumor effect with an IR of approximately 85%, the IR of Ethynylcytidine once weekly is less than 60% and its antitumor effect is rather weak.

DNA Damage/DNA Repair; Nucleoside Antimetabolite/Analog