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MT-DADMe-ImmA Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764266

MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MT-DADMe-ImmA, Inhibitor
Full Product Name
MT-DADMe-ImmA
Product Gene Name
MT-DADMe-ImmA, inhibitor
Product Synonym Names
Methylthio-DADMe-Immucillin A
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
293.39
Solubility
DMSO: 30mg/mL (102.25mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C13H19N5OS
SMILES
CSC[C@@H](CN(Cc1c[nH]c2c(N)ncnc12)C1)[C@H]1O
CAS Number
653592-04-2
Cell Research
Cell viability is evaluated using the Alamar Blue assay. Cells are seeded onto 96-well plates at a density of 10^4cells/well and incubated with increasing concentrations of MT-DADMe-ImmA (100pM to 100uM) for 4 days at fixed MTA concentrations (0, 5, 10, and 20uM) [2].
In Vitro
MTAP activity slowly returns, giving a biological half-life for the action of oral MT-DADMe-ImmA of 6.3 days. The time-dependent growth of FaDu tumors in immunodeficient mice is suppressed by oral or intraperitoneal treatment with MT-DADMe-ImmA [2].

Product References and Citations for MT-DADMe-ImmA, inhibitor

Evans GB, et al. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem. 2005 Jul 14;48(14):4679-89.
Evans GB, et al. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem. 2005 Jul 14;48(14):4679-89.
Basu I, et al. A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. J Biol Chem. 2007 Jul 20;282(29):21477-86.
Basu I, et al. A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. J Biol Chem. 2007 Jul 20;282(29):21477-86.

Other Notes

Small volumes of MT-DADMe-ImmA, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MT-DADMe-ImmA purchase

MBS5764266 is an inhibitor targeting MT-DADMe-ImmA.
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