GNE-131 Inhibitor

Name: GNE-131 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764272
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764272

GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GNE-131, Inhibitor

Full Product Name

GNE-131

Product Gene Name

GNE-131, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

442.57

Solubility

DMSO: 120mg/mL (271.14mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H30N4O3S

SMILES

O=S(C1CC1)(Nc1nnc2n1cc(C1CC1)c(OCC1(CC(C3)C4)CC4CC3C1)c2)=O

CAS Number

1629063-81-5

In Vitro

GNE-131 shows low in vivo clearance in dog, rat, and mouse. It also displays excellent efficacy in a transgenic mouse model of induced pain.

Product Categories/Family for GNE-131, inhibitor

Membrane transporter/Ion channel; Sodium Channel

Product References and Citations for GNE-131, inhibitor

Focken T, et al. Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the treatment,of Pain. J Med Chem. 2018 Jun 14;61(11):4810-4831.

Other Notes

Small volumes of GNE-131, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNE-131 purchase

MBS5764272 is an inhibitor targeting GNE-131.