PRN1371 Inhibitor

Name: PRN1371 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764273
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764273

PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1nM for FGFR1/2/3/4 and CSF1R). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PRN1371, Inhibitor

Full Product Name

PRN1371

Product Gene Name

PRN1371, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

561.46

Solubility

DMSO: 12mg/mL (21.38mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C26H30Cl2N6O4

SMILES

CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1

CAS Number

1802929-43-6

Product Categories/Family for PRN1371, inhibitor

Angiogenesis; FGFR; Tyrosine Kinase/Adaptors

Product References and Citations for PRN1371, inhibitor

Brameld KA, et al. Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the treatment,of Solid Tumors. J Med Chem. 2017 Aug 10;60(15):6516-6527.

Other Notes

Small volumes of PRN1371, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRN1371 purchase

MBS5764273 is an inhibitor targeting PRN1371.