AMG837 Inhibitor – AMG 837 Calcium Hydrate

Name: AMG837 Inhibitor; AMG 837 Calcium Hydrate; MyBioSource
Brand: MyBioSource
SKU: MBS5764278
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764278

AMG 837 calcium hydrate is a potent GPR40 agonist(EC50: 13nM) with highly selective over GPR41, GPR43, and GPR120 (EC50 > 10,000nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AMG 837 calcium hydrate (AMG837), Inhibitor

Full Product Name

AMG 837 calcium hydrate

Product Gene Name

AMG837, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

455.45

Solubility

DMSO: 40mg/mL (87.83mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

SMILES

CC#CC(CC(=O)[O-])C1=CC=C(C=C1)OCC2=CC(=CC=C2)C3=CC=C(C=C3)C(F)(F)F.CC#CC(CC(=O)[O-])C1=CC=C(C=C1)OCC2=CC(=CC=C2)C3=CC=C(C=C3)C(F)(F)F.O.[Ca+2]

CAS Number

1259389-38-2

In Vitro

In rats, AMG 837 increases insulin release when glucose levels are elevated [2].

Product Categories/Family for AMG837, inhibitor

Endocrinology/Hormones; GPR

Product References and Citations for AMG837, inhibitor

Houze JB, et al. AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1267-70.
Houze JB, et al. AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1267-70.
Lin DC, et al. AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One. 2011;6(11):e27270.
Lin DC, et al. AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One. 2011;6(11):e27270.

Other Notes

Small volumes of AMG837, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AMG837 purchase

MBS5764278 is an inhibitor targeting AMG837. Also known as AMG 837 calcium hydrate.