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Lumicitabine Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764292

MBS5764292 is an inhibitor targeting Lumicitabine. Lumicitabine (ALS-008176) is an inhibitor of RSV polymerase. More details

Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lumicitabine, Inhibitor
Full Product Name
Lumicitabine
Product Synonym Names
ALS-008176
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
433.86
Solubility
DMSO: 48mg/mL (110.63mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C18H24ClFN3O6
SMILES
ClC[C@@]1(COC(C(C)C)=O)[C@@H](OC(C(C)C)=O)[C@@H](F)[C@](N2C(N=C(N)C=C2)=O)O1
CAS Number
1445385-02-3
In Vitro
In an adult human challenge study, Lumicitabine has shown efficacy against RSV infection[1]. Lumicitabine solubility is adequate to support oral administration in solutions with a relatively low percentage of organic solvent and in aqueous suspensions. High levels ofnMP and NTP are obtained following the oral administration of Lumicitabine to monkeys [2].

Product Categories/Family for Lumicitabine, inhibitor

Product References and Citations for Lumicitabine, inhibitor

DeVincenzo JP, et al. Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study. N Engl J Med. 2015 Nov
DeVincenzo JP, et al. Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study. N Engl J Med. 2015 Nov
Wang G, et al. Discovery of 4\'-chloromethyl-2\'-deoxy-3\',5\'-di-O-isobutyryl-2\'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment,of human respiratory syncytial virus infection. J Med Chem. 2015 Feb
Wang G, et al. Discovery of 4\'-chloromethyl-2\'-deoxy-3\',5\'-di-O-isobutyryl-2\'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment,of human respiratory syncytial virus infection. J Med Chem. 2015 Feb

Other Notes

Small volumes of Lumicitabine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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