Abrocitinib Inhibitor

Name: Abrocitinib Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764295
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764295

Abrocitinib (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803nM for JAK1/2). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Abrocitinib, Inhibitor

Full Product Name

Abrocitinib

Product Synonym Names

PF-04965842

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

323.41

Solubility

DMSO: 120mg/mL (371.05mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C14H20N5O2S

SMILES

CN([C@]1C[C@@H](NS(CCC)(=O)=O)C1)C2=C3C(NC=C3)=NC=N2

CAS Number

1622902-68-4

In Vitro

In the rat adjuvant-induced arthritis model, Abrocitinib (5, 15, 50mg/kg, p.o., daily for 7 days) significantly reduces paw swelling.

Product Categories/Family for Abrocitinib, inhibitor

Angiogenesis; JAK; Chromatin/Epigenetic; JAK/STAT signaling

Product References and Citations for Abrocitinib, inhibitor

Vazquez ML, et al. Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the treatment,of Autoimmune Diseases. J Med Chem. 2018 Feb 8;61(3):1130-1152.

Other Notes

Small volumes of Abrocitinib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Abrocitinib purchase

MBS5764295 is an inhibitor targeting Abrocitinib.