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AZD7986 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764296

AZD7986 is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AZD7986, Inhibitor
Full Product Name
AZD7986
Product Gene Name
AZD7986, inhibitor
Product Synonym Names
INS 1007
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
420.46
Solubility
DMSO: 100mg/mL (237.83mM)
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C23H22N4O4
SMILES
O=C([C@]1OCCCNC1)N[C@](C#N)CC2=CC=C(C3=CC=C(OC(N4C)=O)C4=C3)C=C2
CAS Number
1802148-05-5
Cell Research
Cellular potency is studied using the DPP1-expressing monocytic U937 cell line. Briefly, cells grown in RPMI are plated on 384-well polypropylene v-bottom plates at a density of 5x10^5 cells/mL per well. Added to this is 10uL of AZD7986 at 37 degree C for 60 min, followed by 350uM Gly-Phe-AFC. The well fluorescence is read using a multilabel plate reader. Data are analyzed to calculate pIC50 values.
Kinase Assay
Activation of neutrophil serine proteases is assessed in vitro using primary bone marrow-derived CD34+ neutrophil progenitor cells. Cells are cultured in media supplemented with rhSCF and rhIL-3 for 7 days, and then for a further 7 days in the presence of G-CSF and different concentrations of AZD7986 (38pM to 10uM). After harvesting and lysis with 10% Triton X-100 buffer, cell lysates are kept at -20 degree C until NSP activity analysis.
In Vitro
AZD7986 shows good stability in plasma, with a half-life of >10 hours. AZD7986 inhibits activation of Pr3 and NE, but not CatG, in bone marrow cell lysates in a dose-dependent manner in vivo.

Product Categories/Family for AZD7986, inhibitor

Proteases/Proteasome; Proteasome

Product References and Citations for AZD7986, inhibitor

Doyle K, et al. Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986). J Med Chem. 2016 Oct 27;59(20):9457-9472.

Other Notes

Small volumes of AZD7986, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZD7986 purchase

MBS5764296 is an inhibitor targeting AZD7986.
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