• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

SH5-07 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764310

MBS5764310 is an inhibitor targeting SH5-07. SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 uM). More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SH5-07, Inhibitor
Full Product Name
SH5-07
Product Gene Name
SH5-07, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
625.61
Solubility
DMSO: 50mg/mL (79.92mM) Need ultrasonic
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C29H28F5N3O5S
SMILES
CN(CC(N(Cc1ccc(C2CCCCC2)cc1)c(cc1)ccc1C(NO)=O)=O)S(c(c(F)c(c(F)c1F)F)c1F)(=O)=O
CAS Number
1456632-41-9
Cell Research
Cells are treated with 0-8 uM agent for 24-48 hours. For cell cycle profile analysis, cells are harvested and fixed with 70% ice-cold ethanol and stained with propidium iodide (PI). For apoptosis analysis, cells are collected and stained with FITC-Annexin V using the Apoptosis Detection Kit. Both the DNA content of cells and the Annexin V-positive cells are analyzed by the flow cytometer. Cell cycle phase distribution is analyzed using the Cell-Fit program. Data acquisition is gated to exclude cell doublets.
In Vitro
Tail vein injection or oral gavage delivery of SH5-07 inhibits the growth of 90-150mM^3 established subcutaneous mouse xenografts of human glioma (U251MG) and breast (MDA-MB-231) tumors that harbor aberrantly-active Stat3, associated with decreased Mcl-1, c-Myc, and Cyclin D1 expression. No significant changes in body weights, blood cell counts, or the gross anatomy of organs, or obvious signs of toxicity are observed.

Product Categories/Family for SH5-07, inhibitor

JAK/STAT signaling; STAT

Product References and Citations for SH5-07, inhibitor

Yue P,et al. Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo. Cancer Res. 2016 Feb 1;76(3):652-63.

Other Notes

Small volumes of SH5-07, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000