GSK189254A Inhibitor

Name: GSK189254A Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764323
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764323

GSK189254A (GSK189254) is a new, potent and specific histamine H receptor antagonist (pKi values: 9.59-9.90 and 8.51-9.17 for human and rat H3). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GSK189254A, Inhibitor

Full Product Name

GSK189254A

Product Gene Name

GSK189254A, inhibitor

Product Synonym Names

GSK189254

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

351.44

Solubility

DMSO: 24mg/mL (68.29mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H25N3O2

SMILES

O=C(NC)C(C=N1)=CC=C1OC2=CC(CC3)=C(C=C2)CCN3C4CCC4

CAS Number

720690-73-3

In Vitro

GSK189254 has a high affinity for both recombinant H3 receptors expressed in HEK-293-MSR-II cells and native H3 receptors expressed in the cerebral cortex of several species. GSK189254 generally exhibits a higher affinity for human and pig H3 receptors compared with mouse, rat, and dog H3 receptors. GSK189254 may have therapeutic potential for the symptomatic treatment of dementia in Alzheimer's disease and other cognitive disorders [1].

Product Categories/Family for GSK189254A, inhibitor

GPCR/G Protein; Histamine Receptor

Product References and Citations for GSK189254A, inhibitor

Medhurst AD, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45.
Medhurst AD, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45.
Guo RX, et al. Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice. Br J Pharmacol. 2009 May;157(1):104-17.
Guo RX, et al. Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice. Br J Pharmacol. 2009 May;157(1):104-17.

Other Notes

Small volumes of GSK189254A, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK189254A purchase

MBS5764323 is an inhibitor targeting GSK189254A.