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AF38469 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764343

AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AF38469, Inhibitor
Full Product Name
AF38469
Product Gene Name
AF38469, inhibitor
Product Synonym Names
AF-38469
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20°C for 3 years.
Molecular Weight
324.25
Solubility
DMSO: 40 mg/mL (123.36 mM),( 1 mg/ml refers to the product slightly soluble or insoluble)
Formula
C15H11F3N2O3
CAS Number
1531634-31-7
Targets(IC50)
Neurotensin Receptor
HNMR
Consistent with structure
HPLC
Consistent with structure
Conclusion
The test result is consistent with structure.
In vitro
AF38469 showed no inhibition or stimulation of >50% at 10 ?M in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition, AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate the evaluation of the therapeutic potential of this protein.

Product Categories/Family for AF38469, inhibitor

GPCR/G Protein

Preparing Stock Solution of AF38469, inhibitor

AF38469 Inhibitor – Cat# MBS5764343

Chemical Structure of AF38469, inhibitor

AF38469 Inhibitor, Chemical Structure – Cat# MBS5764343

Product References and Citations for AF38469, inhibitor

Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80.

Other Notes

Small volumes of AF38469, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AF38469 purchase

MBS5764343 is an inhibitor targeting AF38469.
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