MK-6892 Inhibitor

Name: MK-6892 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764364
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764364

MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4nM; GTPgammaS EC50: 16nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MK-6892, Inhibitor

Full Product Name

MK-6892

Product Gene Name

MK-6892, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

386.4

Solubility

DMSO: 50mg/mL (129.40mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C19H22N4O5

SMILES

CC(C)(Cc1nc(-c(cc2)ncc2O)no1)C(NC(CCCC1)=C1C(O)=O)=O

CAS Number

917910-45-3

Product Categories/Family for MK-6892, inhibitor

Endocrinology/Hormones; GPR

Product References and Citations for MK-6892, inhibitor

Shen HC, et al. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem. 2010 Mar 25;53(6):2666-70.
Shen HC, et al. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem. 2010 Mar 25;53(6):2666-70.
Kim HY, et al. Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor. Arch Pharm Res. 2015 Jun;38(6):1019-32.
Kim HY, et al. Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor. Arch Pharm Res. 2015 Jun;38(6):1019-32.

Other Notes

Small volumes of MK-6892, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MK-6892 purchase

MBS5764364 is an inhibitor targeting MK-6892.