LY3000328 Inhibitor – Ly 3000328

Name: LY3000328 Inhibitor; Ly 3000328; MyBioSource
Brand: MyBioSource
SKU: MBS5764372
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764372

LY 3000328 is a potent, highly selective Cathepsin S (Cat S) inhibitor (IC50s: 7.7 and 1.67nM for hCat S and mCat S). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LY 3000328 (LY3000328), Inhibitor

Full Product Name

LY 3000328

Product Gene Name

LY3000328, inhibitor

Product Synonym Names

Cathepsin S inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

484.52

Solubility

DMSO: 48mg/mL (99.06mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C25H29FN4O5

SMILES

CNC(=O)OC1COC2=C(C1NC(=O)C3=CC=C(C=C3)F)C=C(C=C2)N4CCN(CC4)C5COC5

CAS Number

1373215-15-6

In Vitro

The efficacies of LY3000328 is studied in a mouse model of abdominal aortic aneurysm (AAA). In this model, inflammation is induced using CaCl2 applied to the ablumenal surface. It is shown that the features of the disease state in this model resemble those of human AAA. LY3000328 (1, 3, 10, 30mg/kg) exhibits a dose-responsive aortic diameter reduction. At the lowest dose of 1mg/kg of LY3000328, the aortic diameter is reduced by 58%, then 83% at 3mg/kg, and 87% at 10mg/kg. The exposure (AUC) for both compounds increased in a dose-dependent manner, suggesting that the drug disposition properties of LY3000328 are favorable [1].

Product Categories/Family for LY3000328, inhibitor

Proteases/Proteasome; Cysteine Protease

Product References and Citations for LY3000328, inhibitor

Jadhav PK, et al. Discovery of Cathepsin S Inhibitor LY3000328 for the treatment,of Abdominal Aortic Aneurysm. ACS Med Chem Lett. 2014 Aug 27;5(10):1138-42.
Jadhav PK, et al. Discovery of Cathepsin S Inhibitor LY3000328 for the treatment,of Abdominal Aortic Aneurysm. ACS Med Chem Lett. 2014 Aug 27;5(10):1138-42.
Payne CD, et al. Pharmacokinetics and pharmacodynamics of the cathepsin S inhibitor, LY3000328, in healthy subjects. Br J Clin Pharmacol. 2014 Dec;78(6):1334-42.
Payne CD, et al. Pharmacokinetics and pharmacodynamics of the cathepsin S inhibitor, LY3000328, in healthy subjects. Br J Clin Pharmacol. 2014 Dec;78(6):1334-42.

Other Notes

Small volumes of LY3000328, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LY3000328 purchase

MBS5764372 is an inhibitor targeting LY3000328. Also known as LY 3000328.