AMG232 Inhibitor

Name: AMG232 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764383
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764383

AMG 232 is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6nM). It binds to MDM2 with a Kd of 0.045nM. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AMG232, Inhibitor

Full Product Name

AMG232

Product Gene Name

AMG232, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

568.55

Solubility

DMSO: 50mg/mL (87.94mM)
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C28H35Cl2NO5S

SMILES

CC(C)[C@@H](CS(C(C)C)(=O)=O)N([C@@H]([C@H](C[C@]1(C)CC(O)=O)c2cccc(Cl)c2)c(cc2)ccc2Cl)C1=O

CAS Number

1352066-68-2

Cell Research

Cell Line: SJSA-1, HCT116, ACHN, NCI-H460, MOLM-13, RKO, MCF7, 22RV1, HT-29, PC-3, NCI-H82, NCI-SNU1, MG-63, NCI-H2452, SW982, C32, SK-HEP-1, A375, RT4, RPMI2650, MDA-MB-134-VI, NCI-H2347, and A427 cells. Concentration: 0-10uM [1]. Incubation Time: 72 hours.

In Vitro

AMG 232 (10, 25, 75mg/kg, once daily, p.o.) activates p53 pathway activity in vivo and potently inhibits the growth of tumor xenografts in mice. It also blocks DNA synthesis and induces apoptosis in vivo[1]. AMG 232 causes a dose-dependent tumor growth inhibition with an ED50 of 16mg/kg [2].

Product Categories/Family for AMG232, inhibitor

Apoptosis; Mdm2

Product References and Citations for AMG232, inhibitor

Canon J, et al. The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents. Mol Cancer Ther. 2015 Mar;14(3):649-58.
Canon J, et al. The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents. Mol Cancer Ther. 2015 Mar;14(3):649-58.
Rew Y, et al. Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. J Med Chem. 2014 Aug 14;57(15):6332-41.
Rew Y, et al. Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. J Med Chem. 2014 Aug 14;57(15):6332-41.

Other Notes

Small volumes of AMG232, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AMG232 purchase

MBS5764383 is an inhibitor targeting AMG232.