WR1065 Inhibitor – Wr 1065

Name: WR1065 Inhibitor; Wr 1065; MyBioSource
Brand: MyBioSource
SKU: MBS5764389
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764389

WR-1065 dihydrochloride can activate p53 through a JNK-dependent signaling pathway. It also protect normal tissues from the toxic effects of certain cancer drugs. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

WR 1065 (WR1065), Inhibitor

Full Product Name

WR 1065

Product Gene Name

WR1065, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

207.16

Solubility

Water: 100mg/mL (482.72mM)
DMSO: 24mg/mL (115.85mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C5H16Cl2N2S

SMILES

C(CN)CNCCS.Cl.Cl

CAS Number

14653-77-1

Cell Research

For Western analysis, cells are treated with 1mM WR-1065 for 24 hours, and subconfluent cultures of cells are harvested and lysed in RIPA buffer supplemented with protease inhibitors. Protein concentrations are determined by a detergent-compatible assay. Western blots are blocked and incubated in antibody in PBS/0.2% Tween 20/5% nonfat dry milk. Blots are incubated with 1ug/mL antibody for 1 hour at room temperature, followed by washing in PBS/0.2% Tween 20 and incubation in peroxidase-conjugated secondary antibody and chemiluminescence detection [2].

Product Categories/Family for WR1065, inhibitor

Apoptosis; p53

Product References and Citations for WR1065, inhibitor

Pluquet O, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278(14):11879-87.
Pluquet O, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278(14):11879-87.
Shen H, et al. Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. J Pharmacol Exp Ther. 2001 Jun;297(3):1067-73.
Shen H, et al. Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. J Pharmacol Exp Ther. 2001 Jun;297(3):1067-73.
Afshin Kheradmand, et al. Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats. Iran J Basic Med Sci. 2016 May; 19(5): 490-496.
Afshin Kheradmand, et al. Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats. Iran J Basic Med Sci. 2016 May; 19(5): 490-496.

Other Notes

Small volumes of WR1065, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WR1065 purchase

MBS5764389 is an inhibitor targeting WR1065. Also known as WR 1065.