EIPA Inhibitor

Name: EIPA Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764413
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764413

EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5uM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EIPA, Inhibitor

Full Product Name

EIPA

Product Gene Name

EIPA, inhibitor

Product Synonym Names

L593754

Form/Format

Solid. Powder

Purity/Purification

98.52%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

299.76

Solubility

DMSO: 135mg/mL (450.36mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C11H18ClN7O

SMILES

CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N

CAS Number

1154-25-2

Cell Research

The effect of EIPA alone (without alanine or proline) is also examined in both control (DMEM cultured cells) and amino acid-starved cells. The cells are incubated for 6 h in DMEM containing 5% FBS and either 0 or 0.3mM EIPA (labeled QNN and QNE, respectively), HBSS containing either 0 or 0.3mM EIPA (labeled HNN and HNE, respectively), HBSS with 1.0mM alanine (labeled HAN) or 0.5mM proline (labeled HPN), HBSS with 1.0mM alanine and 0.3mM EIPA (labeled HAE), and HBSS with 0.5mM proline and 0.3mM EIPA (labeled HPE) [2].

Product Categories/Family for EIPA, inhibitor

Membrane transporter/Ion channel; TRP/TRPV Channel

Product References and Citations for EIPA, inhibitor

Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85.
Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85.
Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429.
Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429.
Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis. Oncotarget. 2017 Feb 28;8(9):14748-14758.
Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis. Oncotarget. 2017 Feb 28;8(9):14748-14758.

Other Notes

Small volumes of EIPA, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EIPA purchase

MBS5764413 is an inhibitor targeting EIPA.