PF06650833 Inhibitor

Name: PF06650833 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764423
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764423

PF06650833 is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) (IC50s: 0.2 and 2.4nM in the cell and PBMC assay). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PF06650833, Inhibitor

Full Product Name

PF06650833

Product Gene Name

PF06650833, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

361.37

Solubility

DMSO: 30mg/mL (83.02mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C18H20FN3O4

SMILES

CC[C@@H]([C@@H](COc(c1c2)nccc1cc(C(N)=O)c2OC)NC1=O)[C@@H]1F

CAS Number

1817626-54-2

Product Categories/Family for PF06650833, inhibitor

Immunology/Inflammation; Antiviral

Product References and Citations for PF06650833, inhibitor

Lee KL, et al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13;60(13):5521-5542.

Other Notes

Small volumes of PF06650833, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PF06650833 purchase

MBS5764423 is an inhibitor targeting PF06650833.