14-Deoxy-11,12-didehydroandrographolide Inhibitor

Name: 14-Deoxy-11,12-didehydroandrographolide Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764440
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764440

14-Deoxy-11,12-didehydroandrographolide has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-kappaB activation. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

14-Deoxy-11,12-didehydroandrographolide, Inhibitor

Full Product Name

14-Deoxy-11,12-didehydroandrographolide

Product Synonym Names

14-dehydro Andrographolide

Form/Format

Solid. Powder

Purity/Purification

99.13%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

332.43

Solubility

DMF: 100mg/mL (300.82mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H27O4

SMILES

O=C1OCC=C1/C=C/[C@@H]2C(CC[C@]3([H])[C@](C)(CO)[C@](O)CC[C@@]23C)=C

CAS Number

42895-58-9

Cell Research

A549 cells (3x10^3/well), BEAS-2B cells (5x10^3/well), and RBL-2H3 cells (3x10^3/well) are seeded in flat-bottomed 96-well plates overnight and then incubated with increasing concentrations (3-120uM) of 14-deoxy-11,12-didehydroandrographolide for 24 and 48 hours at 37 degree C. Cell viability is analyzed using the CellTiter 96 AQueous cell proliferation assay. Absorbance is recorded at 490nM.

In Vitro

14-deoxy-11,12-didehydroandrographolide (1mg/kg) dramatically reduces resistance and restores Cdyn in Ovalbumin-challenged mice in response to methacholine.

Product Categories/Family for 14-Deoxy-11,12-didehydroandrographolide, inhibitor

NF-kappab; NF-kappaB

Product References and Citations for 14-Deoxy-11,12-didehydroandrographolide, inhibitor

Guan SP, et al. Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue ofandrographolide, in allergic airway inflammation. J Nat Prod. 2011 Jun 24;74(6):1484-90.

Other Notes

Small volumes of 14-Deoxy-11,12-didehydroandrographolide, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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MBS5764440 is an inhibitor targeting 14-Deoxy-11,12-didehydroandrographolide.