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SR-3677 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764442

MBS5764442 is an inhibitor targeting SR-3677. SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: ~3nM). More details

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Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SR-3677, Inhibitor
Full Product Name
SR-3677
Product Gene Name
SR-3677, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
408.45
Solubility
DMSO: 40mg/mL (97.93mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H24N4O4
SMILES
CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)C3COC4=CC=CC=C4O3
CAS Number
1072959-67-1
Kinase Assay
5uL mixture of a 1uM STK2 substrate and ATP (ROCK-I: 4uM; ROCK-II: 20uM) in STK-buffer is added to the wells. 20 nL of test compounds (SR-3677) is dispensed. The reaction is started by addition of 5uL of 2.5nM. ROCK-I or 0.5nM ROCK-II in STK-buffer. After 4 hours at RT, the reaction is stopped by the addition of 10uL of 1x antibody and 62.5nM Sa-XL in the detection buffer.
In Vitro
SR-3677 has an IC50 of ~3nM in enzyme and cell-based assays and has an off-target hit rate of 1.4% against 353 kinases, and inhibits only 3 out of 70 non-kinase enzymes and receptors. The IC50 value of SR-3677 for ROCK-I is 56nM.

Product Categories/Family for SR-3677, inhibitor

Cell Cycle/Checkpoint; ROCK

Product References and Citations for SR-3677, inhibitor

Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5.

Other Notes

Small volumes of SR-3677, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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