Dimethylcurcumin Inhibitor

Name: Dimethylcurcumin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764467
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764467

Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Dimethylcurcumin, Inhibitor

Full Product Name

Dimethylcurcumin

Product Synonym Names

ASC-J9

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

396.43

Solubility

DMSO: 48mg/mL (121.08mM)
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H24O6

SMILES

COc(ccc(/C=C/C(/C=C(/C=C/c(cc1)cc(OC)c1OC)\O)=O)c1)c1OC

CAS Number

52328-98-0

Cell Research

For the cell survival assay, the PC12/AR-112Q and PC12/AR-10Q cells are cultured as described previously and incubated cells in the presence of 10ug/mL doxycycline for 24 hours. Then the cells are treated with a vehicle, 5uM Dimethylcurcumin or 10uM Dimethylcurcumin, along with 1nM DHT, and determined cell viability using Trypan blue staining at specific time intervals [2].

In Vitro

Dimethylcurcumin (75mg/kg, i.p.) degrades both fAR and AR3 in the xenografted tumors in vivo and ASC-J9-treated tumors have significantly decreased Ki67-positive cells [1]. Dimethylcurcumin (50mg/kg every 48 hours, i.p.) substantially ameliorates the SBMA symptoms in AR-97Q mice and ameliorates neuromuscular pathological findings [2]. ASC-J9-treated mice show significantly smaller prostate tumor sizes when compared with those receiving classic ADT/castration with little serum androgen [3].

Product Categories/Family for Dimethylcurcumin, inhibitor

Endocrinology/Hormones; Androgen Receptor

Product References and Citations for Dimethylcurcumin, inhibitor

Yamashita S, et al. ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors. Neoplasia. 2012 Jan;14(1):74-83.
Yamashita S, et al. ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors. Neoplasia. 2012 Jan;14(1):74-83.
Yang Z, et al. ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat Med. 2007 Mar;13(3):348-53.
Yang Z, et al. ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat Med. 2007 Mar;13(3):348-53.
Lee SO, et al. New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs non-stem/progenitor cells. J Mol Cell Biol. 2012 Jul 24.
Lee SO, et al. New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs non-stem/progenitor cells. J Mol Cell Biol. 2012 Jul 24.
Ma W, et al. Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. Biochem Biophys Res Commun. 2017 Apr 15;485(4):746-752. doi: 10.1016/j. Bbrc.2017.02.123. Epub 2017 Feb 27.
Ma W, et al. Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. Biochem Biophys Res Commun. 2017 Apr 15;485(4):746-752. doi: 10.1016/j. Bbrc.2017.02.123. Epub 2017 Feb 27.

Other Notes

Small volumes of Dimethylcurcumin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Dimethylcurcumin purchase

MBS5764467 is an inhibitor targeting Dimethylcurcumin.