Etrasimod Inhibitor

Name: Etrasimod Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764479
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764479

Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88nM in CHO cells). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Etrasimod, Inhibitor

Full Product Name

Etrasimod

Product Synonym Names

APD334

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

457.48

Solubility

DMSO: 25mg/mL (54.64mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C26H26F3NO3

SMILES

FC(F)(F)C1=CC(COC2=CC=C(NC3=C4CC[C@@H]3CC(O)=O)C4=C2)=CC=C1C5CCCC5

CAS Number

1206123-37-6

In Vitro

In CHO cells expressing HA-tagged S1P1, APD334 is found to have an IC50 value of 1.88nM. Moderate agonism at human S1P4 and S1P5 is observed but is reduced relative to S1P1, both in terms of potency and efficacy. APD334 is devoid of any agonism or antagonism at human S1P2 and S1P3.

Product Categories/Family for Etrasimod, inhibitor

GPCR/G Protein; S1P Receptor

Product References and Citations for Etrasimod, inhibitor

Buzard DJ, et al. Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor. ACS Med Chem Lett. 2014 Nov 4;5(12):1313-7.

Other Notes

Small volumes of Etrasimod, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Etrasimod purchase

MBS5764479 is an inhibitor targeting Etrasimod.