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NVP-CGM097 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764483

MBS5764483 is an inhibitor targeting NVP-CGM097. NVP-CGM097 is an effective and specific MDM2 inhibitor (IC50: 1.7nM for hMDM2). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NVP-CGM097, Inhibitor
Full Product Name
NVP-CGM097
Product Gene Name
NVP-CGM097, inhibitor
Product Synonym Names
CGM097
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
659.26
Solubility
DMSO: 48mg/mL (72.81mM)
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C38H47ClN4O4
SMILES
CC(OC(C=C1[C@]2([H])C3=CC=C(Cl)C=C3)=C(OC)C=C1CC(N2C4=CC=C(N(C[C@@]5([H])CC[C@@](N(CC6=O)CCN6C)([H])CC5)C)C=C4)=O)C
CAS Number
1313363-54-0
Cell Research
Two pairs of cell lines are used to assess NVP-CGM097 p53-dependent antiproliferative effects: (1) an isogenic pair of HCT116 cell lines either expressing wild-type p53 or knocked-out for the p53 gene and (2) a nonisogenic pair of osteosarcoma cell lines either endogenously expressing wild-type p53 and amplified for MDM2 (SJSA-1 cells) or null for p53 (SAOS-2 cells).

Product Categories/Family for NVP-CGM097, inhibitor

Apoptosis; Mdm2

Product References and Citations for NVP-CGM097, inhibitor

Holzer P, et al. Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. J Med Chem. 2015 Aug 27;58(16):6348-58

Other Notes

Small volumes of NVP-CGM097, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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