Traxoprodil Inhibitor

Name: Traxoprodil Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764485
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764485

Traxoprodil (CP101,606) is a selectivenMDA antagonist and protects hippocampal neurons (IC50: 10nM). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Traxoprodil, Inhibitor

Full Product Name

Traxoprodil

Product Synonym Names

CP101606

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

327.42

Solubility

DMSO: 145mg/mL (442.86mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H25NO3

SMILES

C[C@@H]([C@H](c(cc1)ccc1O)O)N(CC1)CCC1(c1ccccc1)O

CAS Number

134234-12-1

In Vitro

Traxoprodil is potent at blocking haloperidol-induced catalepsy and with an ED50 less than 1mg/kg. Traxoprodil is effective at 1mg/kg to blocknMDA (i.p.) stimulated c-fos induction in mice [1]. Traxoprodil at a dose of 20 and 40mg/kg exhibits antidepressant activity in the forced swim test and it is not related to changes in animals' locomotor activity [2]. Traxoprodil (20nM i.c.v.) increases the latency to generalized tonic-clonic seizures induced by PTZ (70mg/kg; i.p.). Traxoprodil (60mg/kg, p.o.) increases the latency to clonic and generalized seizures and decreases the total time spent in seizures [3].

Product Categories/Family for Traxoprodil, inhibitor

Neuroscience; nMDAR

Product References and Citations for Traxoprodil, inhibitor

Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38(16):3138-45.
Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38(16):3138-45.
Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of thenMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31(4):803-14.
Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of thenMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31(4):803-14.
Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100(1-2):12-9.
Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100(1-2):12-9.

Other Notes

Small volumes of Traxoprodil, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Traxoprodil purchase

MBS5764485 is an inhibitor targeting Traxoprodil.