Lemborexant Inhibitor

Name: Lemborexant Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764489
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764489

Lemborexant (E-2006) is a reversible and orally active dual antagonist of the orexin OX1 and OX2 receptors (IC50s: 6.1nM and 2.6nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Lemborexant, Inhibitor

Full Product Name

Lemborexant

Product Synonym Names

E-2006

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

410.42

Solubility

DMSO: 30mg/mL (73.10mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C22H20F2N4O2

SMILES

Cc(nc(C)nc1)c1OC[C@@](C1)([C@@H]1C(Nc(cc1)ncc1F)=O)c1cc(F)ccc1

CAS Number

1369764-02-2

In Vitro

Lemborexant is administered orally to pregnant rats during the period of organogenesis in 2 studies at doses of 60, 200, and 600mg/kg/day or 20, 60, and 200mg/kg/day, which are approximately 6 to >300 times the maximum recommended human dose (MRHD) based on AUC. Lemborexant causes maternal toxicity that consisted of decreased body weight and food consumption and toxicity to offspring consisting of decreased pup body weights, decreases femur length, and decreases acoustic startle responses at 206 times the MRHD based on AUC. The no observed adverse effect levels (NOAEL) of 100mg/kg/day is approximately 93 times the MRHD based on AUC [2].

Product Categories/Family for Lemborexant, inhibitor

GPCR/G Protein; OX Receptor

Product References and Citations for Lemborexant, inhibitor

OREXIN RECEPTOR ANTAGONIST PROVEN EFFECTIVE FOR BOTH SLEEP ONSET AND SLEEP MAINTENANCE IN CLINICAL DEVELOPMENT PROGRAM OF MORE THAN 2,000 PATIENTS. 2019.
OREXIN RECEPTOR ANTAGONIST PROVEN EFFECTIVE FOR BOTH SLEEP ONSET AND SLEEP MAINTENANCE IN CLINICAL DEVELOPMENT PROGRAM OF MORE THAN 2,000 PATIENTS. 2019.
HIGHLIGHTS OF PRESCRIBING INFORMATION
HIGHLIGHTS OF PRESCRIBING INFORMATION

Other Notes

Small volumes of Lemborexant, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Lemborexant purchase

MBS5764489 is an inhibitor targeting Lemborexant.