PLX51107 Inhibitor

Name: PLX51107 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764505
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764505

PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PLX51107, Inhibitor

Full Product Name

PLX51107

Product Gene Name

PLX51107, inhibitor

Form/Format

Solid. Powder

Purity/Purification

99.75%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

438.48

Solubility

DMSO: 70mg/mL (159.65mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C26H22N4O3

SMILES

C[C@H](N1C=C(C2=C1C=C(C=N2)C1=C(C)ON=C1C)C1=CC=C(C=C1)C(O)=O)C1=CC=CC=N1

CAS Number

1627929-55-8

In Vitro

PLX51107 (2mg/kg, p.o.) inhibits splenomegaly by 75% in the Ba/F3 (murine IL3-dependent pro-B-cell line) splenomegaly mouse model, with the similar effect of 25mg/kg OTX015. PLX51107 (20mg/kg, q.d, p.o.) exhibits potent antileukemic effects in disease models of aggressive CLL and Richter transformation (RT) via oral administration once daily.

Product Categories/Family for PLX51107, inhibitor

Chromatin/Epigenetic; Epigenetic Reader Domain

Product References and Citations for PLX51107, inhibitor

Ozer HG, et al. BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discov. 2018 Apr;8(4):458-477.

Other Notes

Small volumes of PLX51107, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLX51107 purchase

MBS5764505 is an inhibitor targeting PLX51107.