Pralsetinib Inhibitor

Name: Pralsetinib Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764526
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764526

Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Pralsetinib, Inhibitor

Full Product Name

Pralsetinib

Product Synonym Names

Blu667

Form/Format

Solid. Powder

Purity/Purification

97.88%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

533.60

Solubility

DMSO: 95mg/mL (178.04mM)
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C27H30FN9O2

SMILES

COC1(CCC(CC1)C1=NC(C)=CC(NC2=NNC(C)=C2)=N1)C(=O)N[C@@H](C)C1=CN=C(C=C1)N1C=C(F)C=N1

CAS Number

2097132-94-8

In Vitro

Pralsetinib potently inhibits the growth of NSCLC and thyroid cancer xenografts driven by various RET mutations and fusions without inhibiting VEGFR-2. Pralsetinib shows dose-dependent activity against both KIF5B-RET Ba/F3 and KIF5B-RET V804L Ba/F3 allograft tumors with doses as low as 10mg/kg twice daily.

Product Categories/Family for Pralsetinib, inhibitor

Apoptosis; c-RET; Tyrosine Kinase/Adaptors

Product References and Citations for Pralsetinib, inhibitor

Subbiah V, et al. Precision Targeted Therapy With BLU-667 for RET-Driven Cancers. American Association for Cancer Research. 10.1158/2159-8290.CD-18-0338.

Other Notes

Small volumes of Pralsetinib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pralsetinib purchase

MBS5764526 is an inhibitor targeting Pralsetinib.