MK-0557 Inhibitor

Name: MK-0557 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764534
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764534

MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MK-0557, Inhibitor

Full Product Name

MK-0557

Product Gene Name

MK-0557, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

406.41

Solubility

DMSO: 25mg/mL (61.52mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C22H18FN4O3

SMILES

O=C([C@]1CC[C@@](C2=C3C=CN=C2)(OC3=O)CC1)NC4=NN(C5=CC=CC=C5F)C=C4

CAS Number

328232-95-7

In Vitro

MK-0557 antagonizes the effects of the NPY5R-selective agonist on body-weight gain and hyperphagia in C57BL/6J mice and significantly suppresses the body-weight gain in diet-induced obese (DIO) mice. When lean mice on regular chow are switched to a medium high-fat diet (4.2 kcal/g) and treated with MK-0557 at 30mg/kg PO QD, MK-0557 causes a 40% reduction in body-weight gain at day 35 [2].

Product Categories/Family for MK-0557, inhibitor

GPCR/G Protein; Neuronal Signaling

Product References and Citations for MK-0557, inhibitor

Fichtner M, et al. Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2738-43.
Fichtner M, et al. Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2738-43.
Erondu N, et al. Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab. 2006 Oct;4(4):275-82.
Erondu N, et al. Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab. 2006 Oct;4(4):275-82.

Other Notes

Small volumes of MK-0557, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MK-0557 purchase

MBS5764534 is an inhibitor targeting MK-0557.