ONO-AE3-208 Inhibitor

Name: ONO-AE3-208 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764538
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764538

ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ONO-AE3-208, Inhibitor

Full Product Name

ONO-AE3-208

Product Gene Name

ONO-AE3-208, inhibitor

Product Synonym Names

AE 3-208

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

404.43

Solubility

DMSO: 45mg/mL (111.27mM)
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H21FN2O3

SMILES

CC(C(Nc1c(CCCC(O)=O)ccc(C#N)c1)=O)c(c1ccccc11)ccc1F

CAS Number

402473-54-5

In Vitro

In mice, ONO-AE3-208 suppresses the in vivo bone metastasis of PC3 cells [1]. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls [3].

Product Categories/Family for ONO-AE3-208, inhibitor

GPCR/G Protein; Prostaglandin Receptor

Product References and Citations for ONO-AE3-208, inhibitor

Xu S, et al. An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer. Cell Biochem Biophys. 2014 Apr 18.
Xu S, et al. An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer. Cell Biochem Biophys. 2014 Apr 18.
Ren Y, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62(6):1123-8.
Ren Y, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62(6):1123-8.
Xu S, et al. Inhibitory effect of ONO-AE3-208 on the formation of bone metastasis of prostate cancer in mice. Zhonghua Nan Ke Xue. 2014 Aug;20(8):684-9.
Xu S, et al. Inhibitory effect of ONO-AE3-208 on the formation of bone metastasis of prostate cancer in mice. Zhonghua Nan Ke Xue. 2014 Aug;20(8):684-9.

Other Notes

Small volumes of ONO-AE3-208, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ONO-AE3-208 purchase

MBS5764538 is an inhibitor targeting ONO-AE3-208.