Coumestrol Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

268.2

DMSO: <=25mg/mL (93.21mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

C15H8O5

O=C1OC2=C(C=CC(O)=C2)C3=C1C4=CC=C(O)C=C4O3

479-13-0

Coumestrol inhibits proliferation and induces apoptosis in MCF-7 cells, which is prevented by copper chelator neocuproine and ROS scavengers. Coumestrol treatment,induces ROS generation coupled to DNA fragmentation, up-regulation of p53/p21, cell cycle arrest at G1/S phase, mitochondrial membrane depolarization and caspases 9/3 activation [1]. Coumestrol inhibits viability and invasion and induces apoptosis of ES2 (clear cell-/serous carcinoma origin) cells. In addition, immunoreactive PCNA and ERBB2, markers of the proliferation of ovarian carcinoma, are attenuated in their expression in coumestrol-induced death of ES2 cells. Phosphorylation of AKT, p70S6K, ERK1/2, JNK1/2, and p90RSK is inactivated by coumestrol treatment,in a dose- and time-dependent manner [2].