CID-2858522 Inhibitor

Name: CID-2858522 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764552
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764552

CID-2858522 is an effective and specific antigen receptor-mediated NF-kappaB activation inhibitor (IC50: 70nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CID-2858522, Inhibitor

Full Product Name

CID-2858522

Product Gene Name

CID-2858522, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

465.63

Solubility

DMSO: Soluble
(<1mg/ refers to the product slightly soluble or insoluble)

Formula

C28H39N3O3

SMILES

CC(C)(C)c1cc(C(Cn2c(NCCCO)nc3c2cc(C)c(C)c3)=O)cc(C(C)(C)C)c1O

CAS Number

758679-97-9

Cell Research

Cell viability is estimated based on cellular ATP levels. HEK293 cells at a density of 10^5/mL are seeded at 90uL per well in 96-well white plates and cultured overnight. Compounds (e.g., CID-2858522; 1uM, 2uM, 3uM, and 4uM) are added (5 uL in medium) to wells and cells are cultured for 16 h, Finally, 50uL ATPlite solution is added to each well and luminescence activity is read using a luminometer [2].

In Vitro

CID-2858522 exhibits nonlinear pharmacokinetics, showing higher serum levels at the 0.5 h measurement time for the 30mg/kg dose compared to 50mg/kg but displaying typical dose-dependent behavior when measured at t=3 hours. The increasing accumulation seen at a dose of 50mg/kg may be due to a depot effect created by CYP3A4 inhibition. The cohort exhibits clear signs of morbidity at t=3 hours at the 50mg/kg dose [2].

Product Categories/Family for CID-2858522, inhibitor

NF-kappab; NF-kappaB

Product References and Citations for CID-2858522, inhibitor

Okolotowicz KJ, et al. Selective benzimidazole inhibitors of the antigen receptor-mediated NF-kappaB activationpathway. Bioorg Med Chem. 2010 Mar 1;18(5):1918-24.
Okolotowicz KJ, et al. Selective benzimidazole inhibitors of the antigen receptor-mediated NF-kappaB activationpathway. Bioorg Med Chem. 2010 Mar 1;18(5):1918-24.
Peddibhotla S, et al. Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules. J Med Chem. 2010 Jun 24;53(12):4793-7.
Peddibhotla S, et al. Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules. J Med Chem. 2010 Jun 24;53(12):4793-7.

Other Notes

Small volumes of CID-2858522, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CID-2858522 purchase

MBS5764552 is an inhibitor targeting CID-2858522.